Welcome to our Cell Signalling Lab
Research in our laboratory is focused on defining eukaryotic signal transduction pathways, and investigating how mutations in components of these pathways can contribute to human diseases such as kidney disease and cancer. Our research team investigates questions related to these pathways using an interdisciplinary approach which includes modern mouse genetic tools, cell culture models, high-resolution microscopy, large-scale profiling techniques and clinical specimens.
Signal transduction is a central process in multicellular organisms that allows for the exchange of informational cues between and within cells. These cues are interpreted by organized networks of protein interactions inside the cell which regulate complex biochemical events, ultimately converting them into biological responses such as growth, migration, differentiation and survival. Cells have evolved a tremendous ability to selectively activate specific downstream pathways through the formation of distinct protein complexes. Understanding the molecular basis of these interactions is a significant challenge in biology, and it is of key importance in defining how specific mutations can lead to pathological conditions such as kidney disease and cancer.
Latest Lab News
- Nov, 19 2025 — Lab Research Presented at The Metastasis Research Society Early Career Research Meeting
Jones Lab PhD candidate, Hayley Smith, was selected to present “ShcD adaptor protein drives invasion of triple-negative breast cancer cells by aberrant activation of EGFR signaling” at the 2nd MRS Early Career Research Meeting.
- Nov 2, 2025 — Jones Lab at Calgary Conference on Cancer Research
Jones Lab Members Erka Shata and Hayley Smith attended this year’s Canadian Cancer Research Conference (CCRC) where they presented…
- Oct 31, 2025 — Pumpkin carving contest entry
The Jones Lab took a quick trip to Paris and came back with some souvenirs to decorate our pumpkin with for the annual MCB carving contest!
- Sept 18, 2025 — Kidney “Bake” Sale Fundraiser
Our continuously evolving annual kidney “bake sale” fundraiser to support the Kidney Foundation of Canada was a major success this year!
- Sept 16, 2025 — Congratulations Alice
Congratulations to Alice for passing her qualifying exam! The Jones lab has just gained another PhD candidate.