Welcome to our Cell Signalling Lab
Research in our laboratory is focused on defining eukaryotic signal transduction pathways, and investigating how mutations in components of these pathways can contribute to human diseases such as kidney disease and cancer. Our research team investigates questions related to these pathways using an interdisciplinary approach which includes modern mouse genetic tools, cell culture models, high-resolution microscopy, large-scale profiling techniques and clinical specimens.
Signal transduction is a central process in multicellular organisms that allows for the exchange of informational cues between and within cells. These cues are interpreted by organized networks of protein interactions inside the cell which regulate complex biochemical events, ultimately converting them into biological responses such as growth, migration, differentiation and survival. Cells have evolved a tremendous ability to selectively activate specific downstream pathways through the formation of distinct protein complexes. Understanding the molecular basis of these interactions is a significant challenge in biology, and it is of key importance in defining how specific mutations can lead to pathological conditions such as kidney disease and cancer.
Latest Lab News
- December 16, 2024 — Happy Holidays
Happy holidays from the Jones lab!
- Oct 31, 2024 — Happy Halloween
Happy Halloween from the Jones Lab! We had a fun and festive time dressing up as the Twilight Baseball scene for MCB departmental trick-or-treating.
- Oct 2, 2024 — Jones Lab at Vancouver Invadosome Consortium
Hayley Smith and Erka Shata are attending this year’s Invadosome Consortium in Vancouver. Today, Erka presented her work on Nck adaptor proteins!
- Sept 29, 2024 — Jones Lab at the Kidney Walk
Thank you to everyone who participated in this year’s Kidney Walk!
- Sept 24, 2024 — Kidney “Bake” Sale Fundraiser
Our continuously evolving annual kidney “bake sale” fundraiser is happening today to support the Kidney Foundation of Canada. We had lots of treats, appetizers, and even stickers! At our bake sale, we made just over $800 – wow!